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α-单月桂酸甘油酯对免疫系统的影响

工夫:2019-04-18 09:41泉源:未知 作者:admin 点击:

01
 

Why is this so important?

为何这个云云主要?

Korver(2006):

“In general, activation of the immune system decreases performance of modern poultry.To maximize production efficiency, the immune system should be kept in  surveillance mode unless activation is required.“

Korver(2012):

“From a survival standpoint, it is preferable to  alter metabolism from growth towards elimination of the  pathogen.”

Niewold(2010):

“Inflammation whether or not it results from  stress or disease is inversely related to growth. Therefore, research in feed should focus on anti-inflammatory  compounds and anti-inflammatory feed composition.

KEEP THE IMMUNE SYSTEM IN SURVEILLANCE

MODE UNLESS ACTIVATION IS REQUIRED

- - - -

NUTRITIONAL IMMUNOMODULATION

Korver (2006):“一般来说,免疫系统的激活会低落当代家禽的生产能力。为了最大限度天进步消费效力,除非需求激活,不然免疫系统应连结看管形式”。

Korver (2012):“从生计的角度来看,最好是将代谢从发展转变为消弭病原体”

Niewold (2010):“炎症是不是由压力或疾病引发,取发展成反比。因而,饲料研讨应着眼于抗炎化合物和抗炎饲料身分

连结免疫系统监测形式

除非需求激活

- - - -

营养免疫调节

02
 

Innate immunity vs. Adaptive immunity

天赋免疫取适应性免疫

03
 

Nutritional immunomodulation of innate immunity

天赋免疫的营养免疫调节

Costs for growth:inflammation 10-30%

INNATE IMMUITY

Metabolism of the innate immune cells  themselves does not require much nutrients, but an inflammatory response can be  nutritionally costly.

◆Inflammatory response

◆Recruit distant immune cells to site of infection 

◆Change metabolism 

◇Increased metabolic rate (fever)  

◇Reduced feed intake 

◇Breakdown of skeletal muscle to support gluconeogenesis and synthesis of acute phase  proteins in the liver

发展本钱炎症10-30%

天赋免疫

天赋免疫细胞自己的新陈代谢不需要太多营养,但炎症回响反映可能会需求许多营养

◆炎症回响反映

◆将远处的免疫细胞募集到熏染部位

◆改动新陈代谢

◇代谢率增添(发热)

◇削减采食量

◇骼肌的剖析,以支撑肝脏中糖异生和分解急性期蛋白质

04
 

Nutritional immunomodulation of adaptive immunity

适应性免疫的营养免疫调节

Costs for growth:Antibodies up 3%

ADAPTIVE IMMUNITY

Minimal effect on energy and nutrient requirements of the bird, because the nutrients  used for antibody production and expansion of B cell population is minimal.

Nutritional immunomodulation of adaptive immunity therefore generally targets antibody  production.

发展本钱:抗体高达3%

适应性免疫

◆ 对鸟类的能量和营养需求的影响最小,由于用于抗体发生和B细胞群扩增的营养物是最小的

◆因而,适应性免疫的营养免疫调节一般针对抗体的发生

05
 

Results nutritional immunomodulation

发生营养免疫调节

现在我们晓得什么?

Anti-inflammatory effect

抗炎感化

Increasing antibody levels (trial 1)

Higher titer =Higher amount of antibodies against IB = Indication of increased immune response

进步抗体程度(实验1).

更高滴度=针对IB的抗体量更高=注解免疫应对增添

Increasing antibody levels (trial 2)

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进步抗体程度(实验2)

Increasing antibody levels (trial 3)

A) Lincomycin @ 120 gram / ton feed

B)  No AGP, no additives

C)  FRA®  C12 Liquid: 1 kg / 1000 L

D)  FRA®  C12 Liquid: 2 kg / 1000 L

进步抗体程度(实验3)

A)  林可霉素@ 120克/吨饲料

B)  没有抗生素发展促进剂,没有添加剂

C)  FRA®C12液体:1 kg / 1000 L.

D)  FRA®C12液体:2 kg / 1000 L

No negative effect on IB vaccination efficacy:

 Good vaccine uptake (qPCR)

 No IB relevant lesions or symptoms in challenge trial

◆ 对IB疫苗接种结果无负面影响

◆ 疫苗摄取优越 (qPCR)

◆ 在进击实验中没有IB相干病变或症状

Modulating IFN-γ

Interferon-gamma (IFN-γ) is a cytokine that plays an  important role in inducing and modulating a series  of immune responses.

Increasing IFN-γ expression might be an effective  approach against a viral infection in broiler chickens.  (Bhagat et al., 2007)

◆调治IFN-γ

◇干扰素-γ(IFN-γ)是一种细胞因子,在引诱和调治一系列免疫回响反映中起重要作用。

◇增添IFN-γ表达能够是匹敌肉鸡病毒感染的有用要领。(Bhagat等,2007)

 

结论

Based on the reduction in NO production an  anti-inflammatory effect of α-monolaurin is  expected.

Based on significant higher IB titer values  found in different trials, α-monolaurin seemed  to improve the immune response.

No negative effect on vaccine uptake.

Based on the significant higher INF-γ level,  FRA® C12 Dry seemed to stimulate the  activity of the immune system.

◆基于NO发生的削减,α-单月桂酸甘油酯的抗炎感化是能够预感的

 基于在差别实验中发明的更高的IB滴度值,α-单月桂酸甘油酯好像改进了免疫应对

 对疫苗吸取没有负面影响

 基于显着较高的INF-γ程度,FRA®C12Dry好像刺激了免疫系统的活性

06

Immune response to PRRS, are there possibilities for immunomodulation?

 对蓝耳的免疫应对,是不是有免疫调节的可能性?

P-PRRSV: ↑ IL-1, IL-6, IL-10

But we need to control these pro-inflammatory cytokines

下致病性猪滋生取呼吸综合征:↑ IL-1, IL-6, IL-10

但我们需求掌握这些促炎细胞因子

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07
 

Immune response to PRRS, are there possibilities for immunomodulation?

对蓝耳的免疫应对,有免疫调节的可能性吗?

It has been implied that stimulating the innate  immunity is more likely to induce protection in pigs  against PRRSV. Therefore, immunomodulation is of  interest, but very complex as PRRSV itself is definitely  an immunomodulator (e.g.suppression of IFN  responses).

Three aims should be considered within an immunomodulation strategy:

◆ To maintain the homeostatic regulatory functions of IFNs during PRRSV infection.

◆ To antagonize the PRRSV-drive amplification of the inflammatory response to LPS. (secondary infections)

◆ To boost antiviral innate immunity

那注解,刺激天赋免疫更有可能引诱珍爱猪匹敌PRRSV。因而,免疫调节是有意义的,但异常庞大,由于PRRSV自己绝对是一种免疫调节剂(比方抑止干扰素IF回响反映)。

在免疫调节战略中应思索三个目的:

◆  在PRRSV熏染时期保持IFN的稳态调治功用

◆  匹敌PRRSV驱动脂多糖的炎症回响反映的放大。(继发熏染)

◆  加强抗病毒天赋免疫力

08
 

 

How does alpha-monolaurin works against PRRS?

α-单月桂酸甘油酯是怎样匹敌蓝耳的呢?

COLLABORATION WITH GD ANIMAL HEALTH TO GET MORE ANSWERS!

GD植物康健部协作得到更多谜底!

 

泉源:荷兰FRAmelco/佰高威衰公司

声明:本文为“华康植物康健服务平台”所有,未经允许,制止转载!谢谢合作

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